We consider random polytopes in the $d$-dimensional Euclidean space that are the convex hulls i.i.d. random points selected according to beta-prime distributions. These distributions are rotationally symmetric, heavy-tailed, and their support is the entire space, making them distinct from other commonly studied distributions, for instance, the uniform and Gaussian distributions. We prove lower bounds for the variances of the intrinsic volumes and the $f$-vector of such random polytopes. Beta-prime random polytopes are the push-forwards of spherical random polytopes, which are the convex hulls of random points chosen in the upper open hemisphere according to some rotationally symmetric distribution, including the uniform distribution in the open half-sphere. Our variance lower bounds also transfer to the spherical settings.